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. 2017 Feb 6;7:42016. doi: 10.1038/srep42016

Figure 3. Mortalin overexpression that caused drug resistance was reverted by knockdown of mortalin with specific shRNA.

Figure 3

Mortalin-overexpressing MDA-MB 231 (A) and MCF-7 (B) cells showed higher viability when treated with a variety of drugs indicating drug resistance characteristics. Knockdown of mortalin with shRNA sensitized the cells to drugs (C).