Figure 8. MCL inhibits the inflammatory response in mice and relieves organ damage caused by methicillin-resistant Staphylococcus aureus (MRSA) infection.

Infective mouse model was carried out by intraperitoneal injection with MRSA (ST 239) (2 × 10⁸ CFU/mouse) in C57BL/6 J mice. Mice were divided into 6 groups (N = 5/group): PBS group, MCL (10 mg/kg) group, MRSA group, MRSA + MCL group, MRSA + dexamethasone (DXM, 7 mg/kg) group, and MRSA + DXM + MCL group. Mice were injected with MRSA and different reagents simultaneously. Twelve hours later, mice were sacrificed and blood samples were clotted and centrifuged at 4 °C. The secretion of IL-6 (a), TNF-α (b), MCP-1 (c) and IFN-γ (d) were measured by CBA method. Data are shown as mean ± SE of 5 mice per group. **Indicates p < 0.01. (e) H&E-staining of liver or kidney tissue sections from the indicated groups (×200). N = 3/group.