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. 2017 Feb 6;36:24. doi: 10.1186/s13046-017-0492-6

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Scheme 1 — Self-assembly processes and structure of the RDMSNs and pH-responsive targeted drug delivery. Drug loading and rituximab conjugation processes of RDMSNs, and illustration of the uptake and internalization of the RDMSNs via a CD20 antigen-mediated interaction and pH-triggered DOX release in lysosome or endosome of the lymphoma B cells