Figure 12.

Intracoronary adenoviral S100A1 gene delivery reverses fetal gene expression and aberrant protein expression in failing myocardium in vivo. (A) Reversed fetal gene expression after S100A1 gene delivery in failing myocardium in vivo (*P < 0.05 HF-AdS100A1 vs. HF-control; n = 4; samples were obtained from 3 different animals in each group). (B) Impact of S100A1 gene addition on SERCA2, PLB, and NCX protein amount in failing myocardium in vivo compared with saline-treated and AdGFP-treated failing myocardium (n = 4; samples were obtained from 3 different animals in each group). Data are presented as mean ±SEM.