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. 2004 Dec 1;114(11):1624–1634. doi: 10.1172/JCI22831

Figure 1.

Figure 1

Rolipram reverses the impairment of L-LTP in the CA1 region of slices from 3-month-old APP/PS1 mice. (A) BST is similar in 3-month-old APP/PS1 animals and WT littermates. Summary graph of field input-output relationship for different stimulation intensities (5_35 V) [F(1, 44) = 0.091, P > 0.05]. (B) Summary graph showing that 20 minutes of treatment with rolipram does not affect L-LTP and baseline transmission in WT mice [F(1, 26) = 0.87, P > 0.05]. (C) Summary graph showing that rolipram abrogates L-LTP impairment in APP/PS1 mice without affecting basal neurotransmission. These experiments were interleaved with those of WT mice [F(1, 23) = 12.48, P < 0.001]. Arrows indicate time and pattern of the tetani.