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. 2004 Dec 1;114(11):1624–1634. doi: 10.1172/JCI22831

Figure 3.

Figure 3

Daily injections of rolipram for 3 weeks in 3-month-old APP/PS1 mice improve radial-arm water maze and Morris water maze performance in 6- to 7-month-old APP/PS1 mice. (A) Impairment of learning and memory during radial-arm water maze testing in APP/PS1 mice is ameliorated by previous treatment with rolipram. Rolipram does not affect the performance of WT mice. Two-way ANOVA revealed a significant overall difference between vehicle-treated APP/PS1 and WT littermates [F(1, 22) = 13.53, P < 0.01] as well as vehicle-treated and rolipram-treated APP/PS1 mice [F(1, 22) = 4.89, P < 0.05]. (B) The performance of APP/PS1 mice in the Morris water maze is improved by previous treatment with rolipram. Two-way ANOVA showed no significant difference in the overall performance of rolipram-treated APP/PS1 mice compared with that of vehicle-treated APP/PS1 mice [F(1, 22) = 0.36, P > 0.05]. However, planned comparisons of latency on each individual session revealed a significant difference between rolipram-treated APP/PS1 mice and vehicle-treated APP/PS1 mice in the sixth session (P < 0.05). (C) In the probe test, APP/PS1 mice previously treated with rolipram search significantly more time in the target quadrant, where the platform was located during training, than do vehicle-treated APP/PS1 littermates (P < 0.05). Rolipram has no effect on WT mice (P > 0.05).