Table 3.
Association between cerebral microbleeds (CMB) and MCR, individual MCR criterion, and cognitive tests (p values <0.05 are bolded)
| Location of CMB | MCR aOR (95% CI) p value |
Cognitive complaints aOR (95% CI) p value |
Slow gait aOR (95% CI) p value |
Amnestic test β (95% CI) p value |
Non-amnestic test β (95% CI) p value |
|---|---|---|---|---|---|
| Global | 1.22 (0.32–4.67) 0.774 |
0.24 (0.05–1.14) 0.072 |
1.48 (0.38–5.78) 0.569 |
−1.47 (–3.35 to 0.41) 0.125 |
−0.55 (–1.49 to 0.39) 0.249 |
| Frontal | # | 0.11 (0.01–4.42) 0.244 |
# | −1.55 (–5.74 to 2.63) 0.463 |
−0.46 (–2.73 to 1.80) 0.687 |
| Parietal | 0.88 (0.10–7.83) 0.905 |
# | 0.69 (0.07–6.62) 0.746 |
−2.49 (–5.45 to 0.47) 0.098 |
0.31 (–1.31 to 1.93) 0.706 |
| Temporal | # | 0.35 (0.02–6.15) 0.470 |
# | −0.40 (–6.23 to 5.43) 0.892 |
0.72 (–1.11 to 2.55) 0.437 |
| Basal ganglia | 1.73 (0.20–14.88) 0.616 |
0.17 (0.02–1.98) 0.158 |
4.27 (0.35–52.00) 0.255 |
0.48 (–2.81 to 3.77) 0.775 |
0.21 (–1.35 to 1.77) 0.789 |
| Infra-tentorial | 2.01 (0.09–43.73) 0.657 |
0.12 (0.01–2.89) 0.189 |
2.35 (0.08–70.17) 0.621 |
−1.77 (–5.76 to 2.23) 0.383 |
−1.44 (–3.60 to 0.71) 0.187 |
a
All associations were adjusted for age, gender, education, GDS score, vascular disease, smoking status, global lacunar infarcts, white matter hyperintensity burden score and cortical strokes.
b
The amnestic test is Rey auditory verbal learning test, and non-amnestic test is digit span test.
c
The analysis could not be performed in occipital regions due to limited number of CMB in these regions.
d
#: insufficient data.