Table 2.
Morphologic, immunohistochemical, and cytogenetic features of typical and atypical IHCAs, other HCAs, and other AHNs
| Typical IHCA (SAA+), % (n) |
Other HCA (SAA−), % (n) |
P | Atypical IHCA (SAA+), % (n) |
Other AHN (SAA−), % (n) |
P | |
|---|---|---|---|---|---|---|
| Age ≥50 y | 0 (0/18) | 0 (0/9) | NA | 47 (8/17) | 20 (3/15) | .11 |
| Male sex | 0 (0/18) | 0 (0/9) | NA | 47 (8/17) | 13 (2/15) | .04* |
| Steatosis | 39 (7/18) | 55 (6/11) | .41 | 60 (12/20) | 50 (8/16) | .55 |
| Inflammation | 56 (10/18) | 45 (5/11) | .60 | 50 (10/20) | 19 (3/16) | .05 |
| Telangiectasia | 61 (11/18) | 27 (3/11) | .077 | 50 (10/20) | 13 (2/16) | .02* |
| Ductular reaction | 22 (4/18) | 9 (1/11) | .36 | 10 (2/20) | 0 (0/16) | .19 |
| Atypical morphologic features | 0 (0/18) | 0 (0/11) | NA | 55 (11/20) | 94 (15/16) | .01* |
| β-Catenin activation | 17 (3/18) | 0 (0/11) | .15 | 35 (7/20) | 38 (6/16) | .88 |
| Chromosomal abnormalities | 0 (0/5) | 0 (0/3) | NA | 70 (7/10) | 43 (3/7) | .26 |
Abbreviation: NA, not applicable.
*
P < .05 was considered statistically significant.