. Author manuscript; available in PMC: 2017 Jun 1.

Published in final edited form as: Proteins. 2016 Apr 9;84(6):841–854. doi: 10.1002/prot.25034

Table 1.

The first, second (median), and the third quartiles of the distribution of the best free parameters of the Contact Number (CN) and the Weighted Contact Number (WCN) resulting in the strongest correlations with sequence evolutionary rates. The best parameter distributions are obtained by tuning the free parameters of CN and WCN for individual proteins in the dataset of 209 monomeric enzymes such that the strongest correlation with evolutionary rates is obtained.

Local Packing Density Measure	Best free-parameter

	25% quartile	median	75% quartile
CN	r₀ = 9.3 [Å]	r₀ = 14.3 [Å]	r₀ = 19.6 [Å]
WCN	α = −2.7	α = −2.3	α = −1.5