. Author manuscript; available in PMC: 2017 Jun 1.

Published in final edited form as: Proteins. 2016 Apr 9;84(6):841–854. doi: 10.1002/prot.25034

Table 4.

The percentage of variance of site-specific evolutionary rates explained by Voronoi cell volume (representing the inverse of site-specific packing density) and Weighted Contact Number controlling for cell volume (representing longer-range effects). In each case, the first, second (median) and the third quartiles of the percentage distribution are reported.

Structural Quantity	Percentage of ER Variance Explained

	25% quartile	median	75% quartile
Voronoi Cell Volume	27%	34%	41%
WCN, controlling for Cell Volume	5%	10%	16%