Table 1. Effect of COP on HCT116 cell cycle progression.

COP (μg/mL)	Cell cycle distribution (%)
	G0/G1	S	G2/M
0	54.4 ± 1.14	29.9 ± 0.751	15.6 ± 0.404
1	57.1 ± 0.333*	29.7 ± 0.505	13.2 ± 0.325**
2.5	53.0 ± 0.721	32.6 ± 1.03**	14.4 ± 0.604
5	56.5 ± 0.794	32.1 ± 0.350*	11.4 ± 0.648**
10	62.5 ± 1.13**	24.6 ± 0.127**	12.9 ± 1.02**

HCT-116 cells were treated with COP at 1–10 μg/mL for 24 h and harvested by trypsinization. The cells were stained with PI solution, and 10000 events per experiment were analyzed using a flow cytometer. Values represent mean ± SD with three replicates. *p < 0.05 and **p < 0.01 compared with control.