Table 1. Effect of COP on HCT116 cell cycle progression.
COP (μg/mL) | Cell cycle distribution (%) | ||
---|---|---|---|
G0/G1 | S | G2/M | |
0 | 54.4 ± 1.14 | 29.9 ± 0.751 | 15.6 ± 0.404 |
1 | 57.1 ± 0.333* | 29.7 ± 0.505 | 13.2 ± 0.325** |
2.5 | 53.0 ± 0.721 | 32.6 ± 1.03** | 14.4 ± 0.604 |
5 | 56.5 ± 0.794 | 32.1 ± 0.350* | 11.4 ± 0.648** |
10 | 62.5 ± 1.13** | 24.6 ± 0.127** | 12.9 ± 1.02** |
HCT-116 cells were treated with COP at 1–10 μg/mL for 24 h and harvested by trypsinization. The cells were stained with PI solution, and 10000 events per experiment were analyzed using a flow cytometer. Values represent mean ± SD with three replicates. *p < 0.05 and **p < 0.01 compared with control.