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. 2017 Feb 6;7:41816. doi: 10.1038/srep41816

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The association between 384 CpGs in 82 addiction-related genes and alcohol and nicotine codependence was analyzed using the liner mixed-effect model. There were 17 CpGs survived the Bonferroni adjustment (P < = 0.05/384 = 0.00013; the red dashed-line) in European Americans. Only one CpGs (cg27531267 in the promoter region of HTR2B) survived the Bonferroni correction in both African Americans (AAs) and European Americans (EAs).