Overview of study design. The two stages of the study are shown, divided into five specific periods. MOD-4023 doses are presented as % of the patients’ cumulative weekly r-hGH dose. For MOD-4023 dosing during Stage A, Period II, the reference period was Stage A, Period I. For dosing in Stage B, the reference period was Stage A, Period III. The PK and PD sampling time points are shown along the bottom of the figure. The discontinued cohort is framed in a dashed line.