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. 2017 Jan 17;114(5):E707–E716. doi: 10.1073/pnas.1610383114

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Fig. 2. — Loss of β-catenin promotes a diverse spectrum of tumor pathologies, including features of poor differentiation and altered differentiation status. (A) Tumor pathologies are classified into three main categories: well-differentiated with epithelial features, transdifferentiated with squamous features, and poorly differentiated. Percentage of each pathology subtype is quantified from all tumors collected: Ctnnb1^+/+ErbB2^KI, n = 30; Ctnnb1^fl/+ErbB2^KI, n = 80; Ctnnb1^fl/flErbB2^KI, n = 21. (B) H&E staining (row 1) of the most common form of pathology for each genotype. Tumors were stained for Krt14 (row 2) and Krt6 (row 3) by IHC and costained for Krt8/14 by IHF (row 4). Ctnnb1^+/+ErbB2^KI, n = 6; Ctnnb1^fl/+ErbB2^KI, n = 7; Ctnnb1^fl/flErbB2^KI, n = 5. (Scale bar: 20 μm.)