Fig. 2.

Adaptively convergent genes closely related with limb development. (A) Structural domains of DYNC2H1 protein and the locations of two convergent amino acid sites. The structural domain annotation derives from the SMART database. (B) Comparison of two convergent amino acid substitutions of DYNC2H1 gene among the genomes of 59 Eutherian species and the gene fragments of three other Eutherian species (Ursus thibetanus, Mephitis mephitis, and Procyon lotor). The first convergent site is R3128K and the amino acid K only occurs in giant and red pandas. The second convergent site is K3999R and the amino acid R only occurs in giant and red pandas, Weddell seal, and walrus. (C) Roles of DYNC2H1 and PCNT proteins in IFT and ciliogenesis. DYNC2H1 is a core component of cytoplasmic dynein 2 complex.