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G-SB2KO mice are protected from age-associated weight gain. Mice maintained on a regular chow diet. (A) Body composition of 4-mo-old female mice was determined by DXA scanning (n = 6 per group). (B) A group of male mice were weighed at 3 mo and 9 mo of age. Each line indicates the weight gain for an individual mouse. (C) DXA was then performed on the same mice. n = 5 control, 6 G-SB2KO. Student’s t test **P < 0.01, ***P < 0.001.
