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. 2004 Nov 23;2(12):e408. doi: 10.1371/journal.pbio.0020408

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Copyright: © 2004 Tsai et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Cocaine responses do not vary with the circadian clock. Control (EP1631) flies were raised under LD conditions and assayed for cocaine phenotypes in the crackometer at the indicated Zeitgeber (ZT) times. One-way ANOVA revealed no significant effect of time of day (F = 0.53, p = 0.82, n = 32).

(B) Flies lacking the neuropeptide PDF (pdf⁰¹) display normal cocaine sensitivity. pdf⁰¹ homozygotes (pdf⁰¹/pdf⁰¹) and pdf⁰¹ hemizygotes (pdf⁰¹/Df) showed wild-type responses to cocaine in the crackometer. Individual pairwise comparisons using Student's t-tests revealed no significant differences between control (+/+ and +/Df) and pdf mutant genotypes (p = 0.69, p = 0.97, n = 6–8 experiments)