Fig 1. Structural features of SRPK1.

(A) Domain organization of SRPK1 as presented in ref. 8. The N- and C-terminal conserved kinase subdomains are colored purple and magenta, respectively. The N- and C-terminal spacer regions are colored yellow and green, respectively, while the remaining spacer domain is colored gray. SRPK1(FL): full-length SRPK1; SRPK1 ΔNS1: the crystallized fragment of SRPK1. (B) Overall structure of SRPK1 ΔNS1 as presented in refs 8 and 16. The coloring of the domains is as in (A). Note that the spacer domain is depicted as a loop outside the kinase core.