Fig 7. Histological analysis of aortic arch cross sections at the lesser curvature from ApoE^-/- mice following four week treatments.

(A) Representative Oil Red O stained sections of aortic arch show atherosclerotic lesions found at the lesser curvature of the aortic arch in control and treated mice; 5–8 animals were analyzed per group. Neutral lipids stained red. Movat’s Pentachrome and Picro-Sirius red stained sections are also shown. Four control animals, 5 BTK inhibitor, and 5 MECA:siMMP-9 treated animals were evaluated. (B) Representative Picro-Sirius red stained sections of aortic arches show atherosclerotic lesions found at the lesser curvature of control and treated mice viewed under polarized light. Four control animals, 5 BTK inhibitor, and 5 MECA:siMMP-9 treated animals were evaluated.