Fig 8. Histological analysis of aortic arch cross sections from ApoE^-/- mice following two week treatments.

(A) Representative sections of aortic arch show atherosclerotic lesions found at the initial branch of the innominate artery of control and treated mice, 5 mice per group were analyzed. Movat’s Pentachrome and Picro-Sirius red stained sections are also shown. (B) Representative Picro-Sirius red stained sections of aortic arches show atherosclerotic lesions found at the innominate artery branch of control and treated mice when viewed under polarized light. (C) Representative sections of aortic arches show atherosclerotic lesions found at the lesser curvature of control and treated mice. Movat’s Pentachrome and Picro-Sirius red stained sections are also shown; 4–5 animals per group were evaluated. (D) Representative Picro-Sirius red stained sections of aortic arches show atherosclerotic lesions found at the lesser curvature in control and treated mice when viewed under normal (right) and polarized (left, center) light; 4–5 animals per group were evaluated.