Table 2. Patient characteristics in randomized trials of statins in heart failure patients.
| Trial [Reference] | Mean age (Years) | Male (%) | Inclusion criteria | Population (Ischaemic or non-ischaemic, %) | Mean LVEF (%) | NYHA |
|---|---|---|---|---|---|---|
| AbdulHul E. et al.[40] | 72 | 68 | Mild-moderate HF, LVEF ≤ 45% | Ischaemic, 64 | 35 | II-III |
| Bielecka-D. et al.[41] | 57 | 85 | Stable HF with DC | NR | 29 | I-III |
| Bleske BE. et al.[42] | 56 | 60 | CHF due to NICM, LVEF<40% | Non-ischaemic | 25 | I-III |
| CORONA [13] | 73 | 76 | Ischaemic HF, age ≥ 60, LVEF < 40% | Ischaemic,100 | 31 | II-IV |
| Erbs S.et al. [43] | 62 | 76 | CHF—Ischaemic HF or DC | Ischaemic,28 | 30 | II-III |
| Gissi-HF Investigators [12] | 68 | 77 | CHF, No LVEF restriction | Ischaemic,40 | 33 | II-IV |
| Hammad A. et al. [44] | 67 | 86 | Stable systolic HF | Ischaemic, 57 | 31 | II-III |
| Hong et al.[58] | 61 | 72 | Patients underwent PCI for AMI | Ischaemic, 100 | 31 | II-IV |
| Horwich TB. et al. [45] | 48 | 62 | Symptomatic HF, LVEF ≤ 35% | Non-ischaemic | 26 | I-III |
| Krum et al. [46] | 62 | 80 | NYHA II-IV, LVEF ≤ 35% or ≤ 40% | Ischaemic,12 | 29 | II-IV |
| Laufs U. et al.[47] | 51 | NR | CHF with NICM | Non-ischaemic | 42 | II-III |
| Liu M. et al. [48] | 67 | 94 | NYHA II-III, CHF with IDCM | Ischaemic/ Non-ischaemic | 20 | II-IV |
| Mozaffarian D.et al. [49] | 51 | 86 | Ambulatory HF, LVEF < 40% | Ischaemic, 9 | 31 | II-III |
| Node K. et al. [50] | 54 | 69 | HF with IDCM | Non-ischaemic | 33 | II-III |
| Sola S. et al. [51] | 54 | 63 | Stable non-ischaemic HF | Non-ischaemic | 33 | II-IV |
| Strey CH. et al. [52] | 61 | 70 | Symptomatic HF, LVEF < 40% | Non-ischaemic | 30 | II-III |
| Takano H. et al.[31] | 63 | 81 | CHF, LVEF ≤ 45% | Ischaemic, 27 | 34 | II-III |
| Tousoulis D.et al.[29] | 69 | 100 | Ischaemic HF, LVEF ≤ 35% | Ischaemic | 25 | III-IV |
| Tousoulis D.et al.[30] | 58 | NR | Stable HF. LVEF ≤ 35% | Ischaemic, 65.7 | 25 | II-IV |
| Vrtovec B. et al. [53] | 67 | 54 | Stable HF, LVEF < 30% | Ischaemic, 62 | 25 | III |
| Vrtovec B. et al. [54] | 62 | 61 | Stable HF, LVEF < 30% | Ischaemic, 59 | 25 | III |
| Wojnicz R. et al. [55] | 38 | 81 | Stable HF with DC | Non-Ischaemic | 28 | II-III |
| Xie RQ. et al.[56] | NR | NR | Ischaemic HF, LVEF<45% | Ischaemic,100 | 38 | II-IV |
| Yamada T. et al.[57] | 64 | 79 | Stable HF, NYHA I-III | Ischaemic, 53 | 34 | I-III |
AMI: acute myocardial infarction; CHF: Chronic Heart Failure; DC: dilated cardiomyopathy; DCM: dilated cardiomyopathy; HF: heart failure; IDCM: idiopathic dilated cardiomyopathy; LVEF: Left Ventricular Ejection Fraction; NICM: Non-Ischaemic Cardiomyopathy; NR: not reported; NYHA: New York Heart Association; PCI: percutaneous coronary intervention.