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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Expert Rev Ophthalmol. 2016 Dec 5;12(1):11–19. doi: 10.1080/17469899.2017.1263567

Table 2.

Treatment regimens of the principal topical medications used for ocular surface squamous neoplasia.

Interferon alpha-2b 5-Fluorouracil Mitomycin C
Regimens Drops:

  • 1 million IU/mL QID until resolution (mean, 4 months)(also 1–3MIU/ml used) [23,58–61]


Injections:

  • 3 million IU/.5cc injection/1–3×week (mean, 4–5 weeks) or 10 million IU/month [55] [56]

 Drops:

  • 1% QID for 1 week followed by 3 weeks off medication [32](mean, 4 cycles)

  • 1% QID for 2–4 days followed by 30 days off medication [30,69](mean, 6 cycles)

  • 1% QID for 4 weeks continuously with 3 months between courses. [68]

 Drops:

  • 0.04%, QID for 1 week followed by 3 weeks off medication(mean, 4 cycles) [90].

  • 0.04% QID 1 week on 1 week off [38,39],[74](reported range 2 to 6 cycles)

  • 0.02% QID for 2–4 weeks [73]

  • 0.002% 4 times daily until resolution [72]

QID= 4 times a day, IU= International units