Table 4.
Univariate- and multivariable-adjusted logistic regression models for in-hospital mortality
| Covariate | Unadjusted OR (95% CI) | P Value | Multivariable-Adjusted OR (95% CI) | P Value |
|---|---|---|---|---|
| Adherence versus nonadherence | ||||
| Higher disease severitya | 1.09 (0.40 to 2.95) | 0.86 | 1.06 (0.38 to 2.95)b | 0.91 |
| Lower disease severitya | 0.22 (0.09 to 0.55) | 0.001 | 0.21 (0.08 to 0.54)b | 0.001 |
| Age at enrollment | 1.02 (1.00 to 1.04) | 0.12 | 1.02 (1.00 to 1.04) | 0.10 |
| Albumin at enrollment | 0.49 (0.29 to 0.82) | <0.01 | 0.49 (0.27 to 0.89) | 0.02 |
Adherence versus nonadherence refers to whether physicians implemented the recommendation regarding initiation of RRT; prespecified subgroups were higher– versus lower–risk disease severity. OR, odds ratio; 95% CI, 95% confidence interval.
a
Higher disease severity indicates >50% predicted risk of mortality. Lower disease severity indicates ≤50% predicted risk of mortality.
b
Model incorporates an interaction term between risk group and adherence; interaction term of disease severity and adherence, P=0.02.