Table 4.
Anemia-related events for HCV+ versus HCV− patients (DOPPS phases 1–5, 1996–2015)
| Event | No. of Events | Crude Ratea | Unadjusted HRb (95% CI) | Adjusted HRc (95% CI) |
|---|---|---|---|---|
| Hemoglobin <8.5 g/dld | 8615 | 112.3 | 1.10 (1.02 to 1.19)e | 1.12 (1.03 to 1.21)e |
| Transfusionf | 3268 | 49.9 | 1.31 (1.15 to 1.48)e | 1.36 (1.20 to 1.55)e |
| Gastrointestinal bleedg | 2093 | 23.6 | 1.28 (1.10 to 1.48)e | 1.32 (1.13 to 1.54)e |
HCV+, hepatitis C virus-positive; HCV−, hepatitis C virus-negative; DOPPS, Dialysis Outcomes and Practice Patterns Study; HR, hazard ratio; 95% CI, 95% confidence interval.
First-events (hemoglobin <8.5 g/dl, transfusion, gastrointestinal bleed) (per 1000 patient years).
Stratified by DOPPS country (United States black and nonblack patients considered as separate strata) and phase and accounting for facility clustering.
Stratified by DOPPS country (United States black and nonblack patients considered as separate strata) and phase and accounting for facility clustering; adjusted for age, sex, time on dialysis, 13 summary comorbidities and hepatitis B infection, and albumin, phosphorus, and creatinine levels.
n=60,319 patients; restricted to patients with baseline hemoglobin ≥8.5 g/dl.
P<0.05.
n=48,253 patients; excludes DOPPS phase 1 where transfusions were not included as an option on the hospitalization worksheet. In phases 2 and 3, transfusions were only ascertained on the hospitalization worksheet (as inpatient or outpatient events); in phases 4 and 5, transfusion events were additionally captured every month on the interval summary; however, dialysis units may not be aware of or record all blood transfusions that patients receive when transfusions occur in a hospital. Large United States dialysis organizations in DOPPS phases 4 and 5 did not provide transfusion events.
n=63,377 patients; large United States dialysis organizations in DOPPS phases 4 and 5 were excluded because of differential reporting of hospitalization cause. Facilities reporting zero hospitalizations during DOPPS follow-up or having <5 cumulative patient-years of hospitalization follow-up were excluded.