Table 5.
Patient-reported measures for HCV+ versus HCV− patients (DOPPS phases 1–5, 1996–2015): Linear regression models
| Quality of Life Measure (Higher=Better) | Outcome Mean | Unadjusted Difference (95% CI)a | Adjusted Difference (95% CI)b |
|---|---|---|---|
| KDQOL-36 Physical Component Summaryc,d | 36.5 | −1.2 (−1.5 to −0.8)e | −0.9 (−1.2 to −0.5)e |
| Physical functioning | 41.8 | −2.9 (−4.0 to −1.7)e | −2.8 (−3.8 to −1.7)e |
| Role-physical | 38.0 | −2.0 (−3.2 to −0.9)e | −2.1 (−3.2 to −0.9)e |
| Bodily pain | 59.6 | −5.6 (−6.6 to −4.6)e | −3.8 (−4.8 to −2.8)e |
| General health | 40.9 | −3.3 (−4.1 to −2.5)e | −2.6 (−3.5 to −1.8)e |
| KDQOL-36 Mental Component Summaryc,d | 44.7 | −1.2 (−1.6 to −0.8)e | −1.2 (−1.6 to −0.8)e |
| Vitality | 38.8 | −2.4 (−3.3 to −1.5)e | −2.3 (−3.2 to −1.4)e |
| Social functioning | 58.3 | −2.5 (−3.5 to −1.5)e | −1.9 (−3.0 to −0.9)e |
| Role-emotional | 54.1 | −2.7 (−3.9 to −1.4)e | −3.3 (−4.5 to −2.0)e |
| Mental health | 62.8 | −2.9 (−3.7 to −2.2)e | −2.2 (−3.0 to −1.5)e |
| KDQOL-36 Kidney Disease Burdenc,d | 36.7 | −1.8 (−2.6 to −1.0)e | −2.1 (−3.0 to −1.3)e |
HCV+, hepatitis C virus-positive; HCV−, hepatitis C virus-negative; DOPPS, Dialysis Outcomes and Practice Patterns Study; 95% CI, 95% confidence interval; KDQOL-36, Kidney Disease Quality of Life instrument.
Adjusted for DOPPS country (United States black and nonblack patients considered separately) and phase and accounting for facility clustering.
Additionally adjusted for age, sex, time on dialysis, 13 summary comorbidities and hepatitis B infection, and albumin, phosphorus, and creatinine levels.
Parameter estimates from linear mixed models represent the modeled difference between HCV+ versus HCV− patients (n=44,320 patients; the models for the subscales had additional patients that did not complete all of the questions necessary to calculate the summary scores, n=50,771–53,576); n=53,596 patients completed the Kidney Disease Burden questions.
Physical and mental component summary and kidney disease burden scores calculated from the KDQOL-36; Lower kidney disease burden score indicates more kidney disease burden. Parameter estimate is from a linear mixed model and represents the modeled difference between HCV+ and HCV− patients (n=44,320 patients).
P<0.05.