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. 2017 Feb 1;11:337–350. doi: 10.2147/DDDT.S121518

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© 2017 Karimian et al. This work is published and licensed by Dove Medical Press Limited

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Immunohistochemical analysis of tumor proliferation markers.

Notes: Ki-67 and PCNA are tumor markers, and brown particles with irregular shapes indicate PCNA and Ki-67 expression (A), LD and HD KME- and tamoxifen-treated groups (B). Ki-67 and PCNA quantification represents the significant reduction in tumor cells after treatment with HD KME and tamoxifen (B). Data are shown as mean ± SEM. Values are statistically significant at *P<0.05. Magnification, 100×.

Abbreviations: HD, high dose; KME, Kelussia odoratissima methanol extract; LD, low dose; SEM, standard error of the mean; TC, tumor control; TT + HD, tumor treated with HD KME; TT + LD, tumor treated with LD KME; TT + TAM, tumor treated with tamoxifen.