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. Author manuscript; available in PMC: 2017 Apr 15.
Published in final edited form as: Biochem Soc Trans. 2016 Apr 15;44(2):505–509. doi: 10.1042/BST20150273

Figure 1.

Figure 1

Schematic of intracellular signaling after antigen-mediated crosslinking of IgE-FcεRI on the surface of mast cells. Binding of antigen-specific IgE to FcεRI sensitizes these receptors to antigen-stimulated signaling that is initiated by a tyrosine phosphorylation cascade. IP3 produced by hydrolysis of PIP2 activates SOCE that is important for granule exocytosis. Activation of protein kinase C (PKC) contributes to the exocytotic response. As described in this review, mitochondria contribute to buffering of cytoplasmic Ca2+ levels. Adapted from [9].