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. 2016 May 20;36(3):e00335. doi: 10.1042/BSR20160062

Figure 3. UCP2 is a bona fide target of miR-214, expression level of which control cell viability.

Figure 3

(A) Cell viability was measured in HLE and HuH6 cells at 24, 48 and 72 h after transfection with miR-214 antagomir or mimic respectively, by the MTT assay. (B) Relative luciferase activity of transiently transfected luciferase reporter constructs containing either full-length or mutated (miR-214-binding sites deleted) UCP2 3’ UTR in indicated cells. (C) Relative luciferase activity of transiently transfected luciferase reporter constructs containing full-length UCP2 3’ UTR in indicated cells, alone or in combination with miR-214 mimic and antagomir.