Figure 1. Schematic representation of HEY1.

The asterisks indicate the two phosphorylated serine residues identified in the proteomic study (Ser-68 and Ser-246). The helix–loop–helix domain of HEY1, HEY2, HEYL, HES1, MYC and MYC-associated factor (MAX), and the region around HEY1 Ser-246 and the equivalent serine in HEY2, HEYL and HES1 were aligned by ClustalW2 and formatted with BOXSHADE. Identical amino acids are in black, and conserved residues are in grey.