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. 2016 Jun 30;36(3):e00352. doi: 10.1042/BSR20160017

Figure 2. Transcriptional and non-transcriptional pathways of E2.

Figure 2

(A) The direct transcriptional pathway involves interaction of ER dimers with EREs within the DNA sequence to modulate gene regulation. (B) The indirect transcriptional pathway involves protein–protein interaction of the ER dimers with transcription factors (TF) to regulate gene transcription. (C) The non-transcriptional pathway involves a subclass of classical ERs and GPER1 to trigger signal transduction cascades in response to E2 stimulation.