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. 2016 Nov 3;36(6):e00403. doi: 10.1042/BSR20160278

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© 2016 The Author(s)

This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution Licence 4.0 (CC BY).

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Panel 1: Representative photomicrographs of perivascular and interstitial fibrosis and inflammatory cell infiltration in left ventricle of control (a and d), CsA-treated (b and e) and CsA+C21-treated rats (c and f). Sirius red staining: interstitial fields, original magnification ×20; perivascular fields, original magnification ×40. Sirius red staining did not show changes in myocardial fibrosis, both at perivascular and interstitial area in CsA-treated rats (b and e) and CsA+C21-treated rats (c and f). Immunohistochemical staining of myocardial inflammatory cell infiltration showed a significant increase in interstitial monocyte/macrophage cells in CsA-treated rats (h) compared with control rats (g). C21 administration did not modify the increase of monocyte/macrophage infiltration in CsA-treated rats (i). Panel 2: Quantification of myocardial perivascular and interstitial fibrosis and monocyte/macrophage inflammatory cells in the different groups of rats. Data are means ± S.E.M. *P<0.01 compared the control group.