Residual distance matrix of apo wild-type, apo Ser111Ala, and apo Ser111Leu BLVRB. Regions of largest conformational change are delineated by black boxes. Residual number of these regions are the same as that in Ref [12]: Loop10 (10–14), Loop40 (40–49), Loop55 (53–57), Loop80 (73–85), Loop120 (110–126), β6a (153–155).