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Energy production provide ATPs for cytoskeletal system, vesicle transport and ionic homeostasis. Ionic homeostasis and vesicle transport are important for lysosomal membrane trafficking pathways including endocytosis, autophagy, exocytosis and retrograde pathway. Cytoskeletal proteins and vesicle transport are important for synaptic transmission. Genes in red represent proteins downregulated in MPS I and genes in green are upregulated.
