Table 2. DAVID functional annotation clustering analysis of all dysregulated proteins.
Count stands for number of genes involved in individual term. P value stands for EASE score (the modified Fisher exact p value). The overall enrichment score based on the EASE scores of each term member. The higher, the more enriched. A cluster is a group of terms having similar biological meaning due to sharing similar gene members. For clustering analysis, classification stringency is set at medium, while enrichment threshold at 0.05.
| Cluster 1 (Enrichment score: 2.14) | |||
|---|---|---|---|
| Functional annotation | Count | P value | Bonferroni |
| Generation of precursor metabolites and energy | 5 | 2.20E-03 | 5.70E-01 |
| Glycolysis | 3 | 3.10E-03 | 3.10E-01 |
| Glucose catabolic process | 3 | 5.50E-03 | 8.80E-01 |
| Hexose catabolic process | 3 | 5.50E-03 | 8.80E-01 |
| Monosaccharide catabolic process | 3 | 5.90E-03 | 9.00E-01 |
| Cellular carbohydrate catabolic process | 3 | 7.20E-03 | 9.40E-01 |
| Alcohol catabolic process | 3 | 8.40E-03 | 9.60E-01 |
| Carbohydrate catabolic process | 3 | 1.30E-02 | 9.90E-01 |
| Glycolysis / Gluconeogenesis | 3 | 2.10E-02 | 6.10E-01 |
| Glucose metabolic process | 3 | 3.60E-02 | 1.00E+00 |
| Cluster 2 (Enrichment score: 1.95) | |||
| Synaptic transmission | 4 | 6.30E-03 | 9.20E-01 |
| Regulation of system process | 4 | 8.80E-03 | 9.70E-01 |
| Transmission of nerve impulse | 4 | 1.20E-02 | 9.90E-01 |
| Cell-cell signaling | 4 | 2.30E-02 | 1.00E+00 |
| Cluster 3 (Enrichment score: 1.64) | |||
| Actin filament organization | 3 | 6.30E-03 | 9.20E-01 |
| Cytoskeleton | 7 | 4.10E-02 | 9.90E-01 |
| Actin cytoskeleton organization | 3 | 4.80E-02 | 1.00E+00 |