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. Author manuscript; available in PMC: 2017 Feb 6.
Published in final edited form as: Mol Genet Metab. 2016 Nov 29;120(1-2):78–95. doi: 10.1016/j.ymgme.2016.11.007

Fig. 2.

Fig. 2

Lateral view of progressive changes of spine with age in a patient (adapted from Educational CD for Morquio and permitted by Carol Ann Foundation). 1 day; a sacral dimple was noted at the delivery and the suspected anterior beaking at the level of L1. It could also be seen in normal baby. 2 months; the anterior beaking was more prominent at the level of L1 with kyphosis. 15 months; unusual kyphosis in the thoracic spine and the gibbus at L1 were prominent with the anterior beaking. L1 vertebral body was compressed. The flaring of the anterior lateral ribs was observed. 32 months; the accentuated dorsal thoracolumbar kypholordosis with the gibbus deformity was noted remarkably. The advanced platyspondylia, irregularity, and anterior bealdng of vertebral bodies are characteristic of MPS IVA.