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. Author manuscript; available in PMC: 2017 Feb 6.
Published in final edited form as: Mol Genet Metab. 2016 Nov 29;120(1-2):78–95. doi: 10.1016/j.ymgme.2016.11.007

Fig. 5.

Fig. 5

Hand deformity in MPS IVA (adapted from Educational CD for Morquio and permitted by Carol Ann Foundation). The radiograph in a 6-year-old patient shows the tapering of the proximal portion of metacarpals 2 through 5 and small irregular carpal bones. The joints may become hyperlaxity by the age of 2 years. The hands with age take on a characteristic with tilting of the radial epiphysis towards the ulna, resulting from a combination of metaphyseal deformities, hypoplasia of the bones, and degradation of connective tissues near the joint secondary to GAG accumulation.