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. Author manuscript; available in PMC: 2017 Feb 6.
Published in final edited form as: Mol Genet Metab. 2016 Nov 29;120(1-2):78–95. doi: 10.1016/j.ymgme.2016.11.007

Fig. 7.

Fig. 7

ERT on Morquio A mice at 8 weeks old treated for 12 (upper) and 24 (lower) weeks with 250 U/g of E6-GALNS. Light microscopy of growth plates in femur from untreated, E6 GALNS-treated, or non-tagged (native) enzyme. An untreated mouse shows marked storage material in chondrocytes (A and D). Vacuolated chondrocytes are obvious. Chondrocytes showed a slight response after 12 and 24 weeks of treatment with native enzyme (C and F). The cartilage cells treated with bone-targeting enzymes have substantial reduction of storage material after 24 weeks of treatment (E). ERT, enzyme-replacement therapy; GALNS, N-acetylgalactosamine-6-sulfate sulfatase.