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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Addict Biol. 2016 Apr 5;22(5):1343–1354. doi: 10.1111/adb.12397

Figure 2.

Figure 2

Models of the indirect associations from individual-level risk factors to heavy episodic drinking at 6 month follow up mediated via peak BrAC during the self-administration (Session 2). Standardized coefficients are shown with standard errors in parentheses. Bolded arrows highlight the indirect associations that are tested. Panel A shows the indirect associations from peak subjective responses during session 1, with coefficients for the stimulation model above the arrows and coefficients for the sedation model below the arrows. Panel B shows the indirect association from OPRM1 (rs1799971) genotype (0=AA, 1=GA/GG), while controlling for race. Panel C shows the 4-variable indirect association from family history (0=negative, 1=positive) to heavy drinking at 6 months mediated through both Session 1 peak stimulation and Session 2 peak BrAC. All models covary for heavy episodic drinking at baseline and number of weeks between baseline and follow up assessments. †p<.10; *p<.05; **p<.01.