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. Author manuscript; available in PMC: 2017 Feb 7.
Published in final edited form as: Chem Res Toxicol. 2016 Aug 11;30(1):2–12. doi: 10.1021/acs.chemrestox.6b00226

Table 5.

Human P450s Known to be Covalently Modified and Inhibited by Drugs

P450 drug
1A2, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, 3A4, 3A5 numerous mechanism-based inhibitors53
11A1 BMS drug candidate (“BMS-A”) (Figure 6)21
27A1 carfilzomib (Figure 5)68