Table 1.
Subgroup-specific septin-septin binding preferences, septin-interacting proteins, and their physiological relevance.
| Septin subgroup | Preferred partner | References | |
|---|---|---|---|
| SEPT6 group | SEPT2 group, SEPT3 group, SEPT7 group | Nakahira et al., 2010; Sandrock et al., 2011 | |
| SEPT2 group | SEPT6 group | Nakahira et al., 2010; Sandrock et al., 2011 | |
| SEPT3 group | SEPT7 group | Nakahira et al., 2010; Sandrock et al., 2011 | |
| Protein | Interacting septin | Physiological relevance | References |
| CENP | Septin 1, 2, 4, 5, 7, 9 | Exocytose, intracellular trafficking | Nakahira et al., 2010 |
| SNX6 | Septin 2, 5, 6, 8, 11 | Exocytose, intracellular trafficking | Nakahira et al., 2010 |
| Sec6/8 | Septin 2, 4, 6, 7 | Vesicle transport | Ihara et al., 2005 |
| Syntaxin1A | Sepin 2, 5 | Vesicle transport | Beites et al., 2001 |
| VAMP1 | Septin 4, 11 | Vesicle transport | Zhang et al., 2000 |
| Transferrin receptor | Septin 4, 11 | Vesicle transport | Zhang et al., 2000 |
| FLNA | Septin 9 | Cytoskeleton organization, vesicle transport | Nakahira et al., 2010 |
| SH3KBP1 | Septin 9 | Cytoskeleton organization, vesicle transport | Nakahira et al., 2010 |
| IFT27 | Septin 3, 7 | Vesicle transport, endocytose | Nakahira et al., 2010 |
| Ra1ABP1 | Septin 3, 7 | Vesicle transport, endocytose | Nakahira et al., 2010 |
| Actin cytoskeleton | Septins | Multiple functions | Kinoshita et al., 2002; Spiliotis et al., 2005 |
| Microtuble cytokeleton | Septins | Multiple functions | Surka et al., 2002; Nagata et al., 2003; Kremer et al., 2005; Joo et al., 2007; Bowen et al., 2011; Mostowy and Cossart, 2012 |
| Pospholipid membrane | Septins | Multiple functions | Spiliotis et al., 2008; Tanaka-Takiguchi et al., 2009 |
| Anillin | Septin 2 | Filament organization | Spiliotis et al., 2005 |
| α-Tubulin | Septin complexes | Regulation of actin and tubulin polymerization | Nagata et al., 2003 |
| Cytochalasin D | Septin 2, 6 | Regulation of actin polymerization | Spiliotis et al., 2005 |
| Latrunculin | Septin 2, 6 | Regulation of actin polymerization | Spiliotis et al., 2005 |
| MAP4 | Septin 2-6-7 complex | Modulation of microtuble dynamics | Bowen et al., 2011 |
| HDAC6 | Septin 7 | Dendritic development | Ghossoub et al., 2013 |
| ERK3 | Septin 7 | Dendritic morphology | Ageta-Ishihara et al., 2013 |
| Aurora-B | Septin 1 | Mitose, cytokinesis | Hu et al., 2012 |
| Cdk1/Pin1 | Septin 9 | Cytokinesis | Qi et al., 2005 |
| Drp1 | Septin 2 | Mitochondrial fission | Estey et al., 2013 |
| Tau, NFTs | Septin 1, 2, 4 | Neuronal differentation and growth | Pagliuso et al., 2016 |
| Parkin | Septin 5 | Regulation of neuronal differentation and growth | Takehashi et al., 2004 |
| α-Synuclein | Septin 4 | Regulation of neuronal differentation and growth | Dong et al., 2003; Ihara et al., 2003 |
| MLL | Septin 5, 6, 9, 11 | Myeloid-lymphoid leukemia | Megonigal et al., 1998; Zieger et al., 2000 |
| BORG3-cdc42 | Septin 6, 7 | Cell polarity, cytokinesis, vesicle transport | Engidawork et al., 2003; Kuo et al., 2015 |
| BORG4-AP-3 | Septin 6, 7 | Regulation of endocytose | Joberty et al., 2001; Baust et al., 2008 |
| KIF17 | Septin 9 | Intracellular protein transport | Nakahira et al., 2010; Traikov et al., 2014 |
| UBE21, SUMO, PIAS | Near all septins | Protein degradation | Nakahira et al., 2010 |