Table 1.

Top 10 domains responsible for separation of mycoplasma functional clusters.

Enriched in haemoplasmaa		Enriched in hominis/spiroplasmab		Enriched in pneumoniaec
IDd	InterPro descriptione	IDd	InterPro descriptione	IDd	InterPro descriptione
IPR026023	Ribonucleotide reductase small subunit, prokaryotic	IPR029048	Heat shock protein 70kD, C-terminal domain	IPR002606	Riboflavin kinase, bacterial
IPR029022	ABC transporter, BtuC-like	IPR013826	DNA topoisomerase, type IA, central region, subdomain 3	IPR003526	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
IPR000522	ABC transporter, permease protein	IPR004398	RNA methyltransferase, RsmD	IPR006660	Arsenate reductase-like
IPR001674	GMP synthase, C-terminal	IPR003442	tRNA threonylcarbamoyl adenosine modification protein TsaE	IPR011631	Protein of unknown function DUF1600
IPR004837	Sodium/calcium exchanger membrane region	IPR006667	SLC41 divalent cation transporters, integral membrane domain	IPR023344	Uncharacterized domain MG237, C-terminal
IPR001670	Alcohol dehydrogenase, iron-type	IPR006668	Magnesium transporter, MgtE intracellular domain	IPR015271	Protein of unknown function DUF1951
IPR001093	IMP dehydrogenase/GMP reductase	IPR016947	Bacteriophage gamma, gammalsu0035	IPR013825	DNA topoisomerase, type IA, central region, subdomain 2
IPR019065	Restriction endonuclease, type II, NgoFVII	IPR000748	Pseudouridine synthase, RsuA/RluB/E/F	IPR012760	RNA polymerase sigma factor RpoD, C-terminal
IPR020471	Aldo/keto reductase subgroup	IPR001525	C-5 cytosine methyltransferase	IPR001844	Chaperonin Cpn60
IPR023210	NADP-dependent oxidoreductase domain	IPR003370	Chromate transporter	IPR002423	Chaperonin Cpn60/TCP-1

^aDomains enriched in haemoplasma functional cluster.

^bDomains enriched in hominis/spiroplasma functional cluster.

^cDomains enriched in pneumoniae functional cluster.

^dInterPro Identifier.

^eDomain description obtained from InterProScan.