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. 2017 Feb 7;7:27. doi: 10.3389/fcimb.2017.00027

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Copyright © 2017 Wang, Liu, Luo, Chen, Li, Su, Zhao, Liu, Xie, Jia, Ding, Wan and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HEK293 cells were transfected with HA-MEK1^K64R mutant and wild-type HA-MEK1. (A) The expression levels of phospho-ERK and HA-MEK. (B) Phosphorylating activity of ERK was significantly higher in the mutant than in the wild type cell. (C,D) Cells that expressed HA-MEK1K⁶⁴R elicited stronger ERK phosphorylation than cells that express wild type HA-MEK1. P values were calculated using a Student's t-test. ^*P < 0.05; ^**P < 0.01.