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. 2017 Feb 7;7:27. doi: 10.3389/fcimb.2017.00027

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Copyright © 2017 Wang, Liu, Luo, Chen, Li, Su, Zhao, Liu, Xie, Jia, Ding, Wan and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SUMOylation of MEK1 negatively regulates virus propagation. Cells infected by influenza virus showed almost completely inhibited MEK1 SUMOylation compared to MOCK cells without virus infection (A). The endogenous ERK pathway was downregulated in HEK293 cells that stably expressed HA-MEK1-Ubc9 (B). The NP gene expression level of influenza virus was downregulated significantly (C). The endogenous ERK phosphorylation was downregulated by stable expression of HA-MEK1-Ubc9 in A549 cells after virus infection (D). P values were calculated using a Student's t-test. ^*P < 0.05; ^**P < 0.01.