Table 2.
Month | 1 | 3 | 6 | 9 | 12 | 18 | 24 | 30 | 36 | |
---|---|---|---|---|---|---|---|---|---|---|
Toxicity | Grade | % | % | % | % | % | % | % | % | % |
Diarrhea | 0 | 75 | 82 | 83 | 74 | 79 | 95 | 78 | 77 | 79 |
1 | 19 | 14 | 13 | 23 | 19 | 5 | 20 | 22 | 21 | |
2 | 7 | 3 | 4 | 3 | 2 | 0 | 2 | 1 | 0 | |
Proctitis | 0 | 90 | 96 | 95 | 95 | 93 | 96 | 95 | 96 | 93 |
1 | 10 | 4 | 5 | 5 | 7 | 4 | 5 | 4 | 7 | |
2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
Rectal bleeding | 0 | 87 | 96 | 87 | 85 | 83 | 84 | 81 | 87 | 87 |
1 | 13 | 4 | 13 | 15 | 12 | 14 | 18 | 13 | 12 | |
2 | 0 | 0 | 0 | 0 | 4 | 2 | 1 | 0 | 1 | |
3 | 0 | 0 | 0 | 0 | 1a | 0 | 0 | 0 | 0 | |
Highest GI | 0 | 62 | 76 | 72 | 66 | 64 | 68 | 65 | 68 | 68 |
1 | 31 | 21 | 24 | 31 | 31 | 29 | 32 | 31 | 31 | |
2 | 7 | 3 | 4 | 3 | 4 | 3 | 3 | 1 | 1 | |
3 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
aPatient with non-healing ulcer required hyperbaric oxygen and was assigned as grade 3 toxicity.