Table 6.

Summary of late ≥grade 2 or 3 toxicities reported for various techniques, including IMRT + SBRT boost.

Author	Institution/trial	Technique	Dose (Gy)	Median follow-up (years)	Pts	Gr 2 genitourinary (GU) (%)	Gr 3 GU (%)	Gr 2 gastrointestinal (GI) (%)	Gr 3 GI (%)
Zelefsky et al. (6)	MSKCC	IMRT/IGRT	86.4	2.8	186	10.4	–	1.0	–
		IMRT/no IGRT			190	20	–	1.6	–
Michalski et al. (31)	Radiation Therapy Oncology Group (RTOG) 0126	3D-CRT	79.2	4.6	491	13.4	2.5	22	5.1
		IMRT		3.5	257	7.8	1.9	15.1	2.6
Mariados et al. (32)	PIVOT	IMRT/No spacer	79.2	1.25	73	4.2	–	1.4	–
		IMRT/spacer			149	6.8		0
King et al. (33)	UCLA/Stanford	SBRT (5 fxns)	36.25	2.7	67	8.8	3.5	2	0
Chen et al. (27)	Georgetown	SBRT (5 fxns)	35–36.25	2.3	100	31	1	1	0
Khor et al. (13)	Melbourne, Australia	HDR boost (3 fxns) + EBRT	19.5 + 46	5	344	16.8a	11.8a	–	–
Hoskin et al. (15)	UK	HDR boost (2 fxns) + EBRT (13 fxns)	17 + 35.75	7.1	110	31b	–	7b	–
Hsu et al. (16)	RTOG 0321	HDR boost (2 fxns) + EBRT	19 + 45	2.5	112	7.1	2.7	2.7	0.9
Rodda et al. (30)	ASCENDE-RT	LDR boost + EBRT	115	6.5	198	–	18	–	9
		EBRT	78		200		8		4
Katz and Kang (21)	Winthrop	SBRT boost (3 fxns) + 3D-CRT	(19 to 21) + 45	5	45	4.6	2.3	13.3	–
Lin et al. (20)	Taiwan	SBRT boost (3 fxns) + VMAT	21 + 45	3.5	41	3–11c	0	0	0
Anwar et al. (23)	UCSF	SBRT boost (2 fxns) + SIB	(9.5 to 10.5) + 45	3.6	48	27	2	0	0
Paydar et al. (24)	Georgetown	SBRT boost + IMRT	19.5 + (45 to 50.4)	4.2	108	40	6	12	1

IMRT, intensity-modulated radiation therapy; IGRT, image-guided radiation therapy; 3D-CRT, 3D-conformal radiation therapy; SBRT, stereotactic body radiation therapy; HDR, high dose rate; LDR, low dose rate; EBRT, external beam radiation therapy; VMAT, volumetric arc therapy; SIB, simultaneous integrated boost.

^aUrethral stricture rates.

^bSevere toxicity per the Dische scale.

^c0–11% toxicity rates in late follow-up period with cumulative rates not reported.