Table 3.
Effects of orthostatic challenge on selected coagulation times and on indicators of endothelial activation.
| Baseline samples | Post standing samples | P-value | |
|---|---|---|---|
| STANDARD COAGULATION TIMES | |||
| Group 1 | |||
| APTT (s) | 36.8 (33.5–38.8) | 34.8 (32.3–41.2) | n.s.b |
| Group 2 | |||
| APTT (s) | 37.2 (32.8–39.0) | 32.9 (30.8–36.3) | <0.001a |
| ENDOTHELIAL ACTIVATION | |||
| Group 1 | |||
| tPA (ng/mL) | 10.1 (8.3–15.5) | 9.4 (7.0–15.0) | n.s.b |
| TF (pg/mL) | 338 (282–531) | 481 (372–591) | 0.019b |
| Group 2 | |||
| tPA (ng/mL) | 7.3 (5.5–11.8) | 9.7 (6.7–13.7) | 0.035a |
| TF (pg/mL) | 459 (362–799) | 491 (302–1047) | n.s.b |
Effects of orthostatic challenge in 22 older patients who had recovered from ischemic stroke (Group 1) compared with 22 healthy age-matched controls (Group 2). Data are expressed as median [interquartile range = (Q1–Q3)]. P-values were calculated by means of the t-test for paired samples (a) in case of normally distributed variables; otherwise the Wilcoxon test (b) was applied. APTT, activated partial thromboplastin time; TF, tissue factor; tPA, tissue-plasminogen activator.