Table 2.

Exclusion criteria for the ExPAH study

Criteria	Characteristics of ineligible participants
1.	General exclusion criteria: Pregnancy Presence of cognitive impairment and/or neuromuscular weakness of sufficient severity to prevent participation in exercise classes Non-primary English language limiting ability to comply with exercise classes WHO Functional Class IV enrolled in a formal exercise training programme within preceding 12 weeks
2.	PAH-specific: Change in PAH medication within preceding 3 months
3.	Presence of significant cardiac disease, including: Unstable angina pectoris (ie, chest pain not controlled with medications) Unstable CCF requiring escalation of medication within preceding 3 months Exercise-induced arrhythmias such as atrial fibrillation, ventricular tachycardia Hypertrophic obstructive cardiomyopathy
4.	Patients unable to undergo MRI: Presence of impaired renal function (eGFR<60 mL/min) due to a possible adverse event with intravenous gadolinium contrast In situ pacemaker or implantable cardiac defibrillator Other metal or electronic implants affected by a magnetic field Shrapnel injuries Previous eye injury involving metal fragments Metal clips in cerebral blood vessels Joint replacement within 3 months Previous serious adverse event to MRI gadolinium contrast agents

CCF, congestive cardiac failure; eGFR, estimated glomerular filtration rate; PAH, pulmonary arterial hypertension.