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. 2017 Feb 1;4(1):e000186. doi: 10.1136/lupus-2016-000186

Table 4.

Functioning by frailty classification: Cross-sectional and longitudinal analyses

  Frailty classification
Robust Prefrail Frail p Value*
Cross-sectional, bivariate
 VLA mean difficulty† 0.29±0.25 0.87±0.45 1.34±0.50 <0.0001
 SF-36 Physical Function† 50.8±7.3 39.3±10.0 30.4±8.7 <0.0001
 Cognitive, % impaired† 20.9 (9) 32.4(23) 50.0 (14) 0.04
Cross-sectional, multivariate
 VLA mean difficulty‡ (reference) 0.34 (<0.0001) 0.62 (<0.0001)
 SF-36 Physical Function‡ (reference) −5.9 (0.0003) −10.5 (<0.0001
 Cognitive, % impaired§ (reference) 2.6 (0.8 to 8.4) 5.9 (1.2 to 28.6)
Longitudinal multivariate
 VLA mean difficulty‡ (reference) 0.11 (0.12) 0.31 (0.002)
 SF-36 Physical Function‡ (reference) 2.4 (0.19) −6.7 (0.01)
 Cognitive, % impaired§ (reference) 5.3 (0.5 to 61.0) 37.3 (1.1 to >999)

Cross-sectional multivariate analyses controlled for age, duration, low education, race, oral steroids, obesity, SLAQ, BILD, SF-36 Pain.

Longitudinal analyses: baseline frailty component/category predicting change in function 2 years later. Controlled for baseline age, duration, low education, race, oral steroids, obesity, SLAQ, BILD, SF-36 Pain and baseline value of function.

*p Value from analysis of variance or χ2 analysis.

†Values are mean±SD, or % (n).

‡Values are β parameter estimate (p value) from multiple linear regression analysis.

§Values are OR (95% CI) from multiple logistic regression analysis.

BILD, Brief Index of Lupus Damage; SLAQ, Systemic Lupus Activity Questionnaire; VLA, Valued Life Activities.

Bold indicates statistical significance.