Fig. 4.

A, Numbers of total tryptic peptides and VIATC consensus peptides detected in four fractions: cytoskeletal, cytoplasmic, membrane + organelle, and nuclear. B, Box-plots of adenocarcinoma (AC)/noncancer (NC) ratios for VIATC consensus peptide abundance in four fractions on the logarithmic scale. Boxes denote interquartile range whereas whiskers extend to the most extreme data point which is no more than 1.5 times the interquartile range from the box. VIATC peptides were significantly more abundant in AC only for the nuclear fraction, indicating that the majority of VIATC nuclear peptides are overrepresented in colon cancer tissue.