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. 2004 Nov 30;1(2):e45. doi: 10.1371/journal.pmed.0010045

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Copyright: © 2004 Lehrke et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) The correlation (Spearman coefficient rho = 0.38, p < 0.001) of plasma resistin and sTNFR2 levels in 215 humans with type 2 diabetes is presented. The line represents the linear regression fit between log-transformed plasma levels of resistin and sTNFR2.

(B) Model to explain hyperresistinemia in mice and humans with obesity despite the species differences in the source of plasma resistin. Circulating inflammatory cytokines TNFα and IL-6 are depicted because of their role in resistin induction in human macrophages and their implied role in insulin resistance. Other cytokines and inflammatory markers may also contribute to insulin resistance and/or resistin induction.